Vaccine technology

Providing solutions for the protection and welfare of domestic and farm animals

  • Collection, culture and identification and selection of potential pathogens for vaccine production.
  • Establishing potential vaccine strain in a selected cell culture system or spf chick embryos
  • Cloning of cell substrates to increase viral titres
  • Establishment from embryonic organs of cloned cell lines/strains - cattle, sheep, horse, rabbit, pig fish etc.
  • Establishing virus purity and identity.
  • Attenuation of vaccine strain including classical mutagenisis.
  • Cloning of attenuated virus.
  • Extraneous agent testing as per EU Pharmacopia.
  • Providing stock of fully tested master virus seed.
  • Develop and optimize vaccine production methods, challenge models and potency tests.
  • Provide stocks of fully tested bulk antigen.
  • Candidate vaccine strains include important pathogens of cattle, sheep, poultry, dogs, cats, rabbits and fish.
  • Validation of inactivation methods.
  • Production of Emergency vaccines under VMD AV authorisation.
  • Technology transfer to CMO for commercial vaccine production.
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Virus diagnostic testing

  • Set up and validate titration methods
  • Neutralising antibody testing.
  • Virus isolation and Virus Identity testing
  • Establish in vitro assays including HA, HAI and ELISA.
  • Immunofluorescent antibody/antigen testing
  • qPCR assay development and validation.
Virus diagnostic testing
Vaccine registration

Vaccine registration

  • Perform studies for EU and non EU registration.
  • Provide advice and support for study protocols for registration studies
  • Development of tests and SOP's
  • Consultation
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Vaccine and cell technology service company

Established in 2004 as a vaccine development company, Marinnovac UK provides a comprehensive range of contract services to animal health care companies.
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One Nucleus